Journal article
Chemical and chemoenzymatic synthesis of glycosyl-amino acids and glycopeptides related to Trypanosoma cruzi mucins.
- Abstract:
-
This study describes the synthesis of the alpha- and beta-linked N-acetyllactosamine (Galp-beta-1,4-GlcNAc; LacNAc) glycosides of threonine (LacNAc-Thr). LacNAc-a-Thr was prepared by direct chemical coupling of a 2-azido-2-deoxy-lactose disaccharide donor to a suitable partially protected threonine unit. In contrast, stepwise chemical generation of beta-linked N-acetylglucosamine followed by enzymatic galactosylation to give LacNAc-beta-Thr proved effective, whereas use of a 2-azido-2-deoxy-l...
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- Publication status:
- Published
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- Publisher copy:
- 10.1039/b707772f
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Authors
Bibliographic Details
- Journal:
- Organic and biomolecular chemistry
- Volume:
- 5
- Issue:
- 16
- Pages:
- 2645-2657
- Publication date:
- 2007-08-01
- DOI:
- EISSN:
-
1477-0539
- ISSN:
-
1477-0520
- Source identifiers:
-
40435
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:40435
- UUID:
-
uuid:8e5cf1b6-ea50-4a79-a761-cf5c21d28e0c
- Local pid:
- pubs:40435
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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