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Identification of CVID patients with defects in immune repertoire formation or specification

Abstract:

Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies. CVID has been associated with a quantitative B cell defect, however, little is known about the quality of B cells present. Here, we studied the naïve and antigen selected B-cell receptor (BCR) repertoire in 33 CVID patients using next generation sequencing, to investigate B cells quality. Analysis for each indiv...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Wellcome Trust
Grant:
109692/Z/15/Z
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
9
Article number:
2545
Publication date:
2018-11-23
Acceptance date:
2018-10-16
DOI:
EISSN:
1664-3224
Pmid:
30532750
Language:
English
Keywords:
Pubs id:
pubs:950510
UUID:
uuid:8e4fda85-a471-4f89-8b4e-0dd7a5a1ac0c
Local pid:
pubs:950510
Source identifiers:
950510
Deposit date:
2019-09-09

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