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Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.

Abstract:

BACKGROUND: "FFM ME-TRAP" is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara) delivering the pre-erythrocytic malaria antigen ME-TRAP. Over nine months follow-up in our original study, there was no evidence that FFM ME-TRAP provided protection against malaria. The incidence of malaria was slightly higher in children who received FFM ME-TRAP, but this was not statistically significant (hazard ratio 1.5, 95% CI 1.0-2.3). Although the study w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0000707

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Institution:
University of Oxford
Milligan, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Funding agency for:
Bejon, P
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Funding agency for:
Marsh, K
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Funding agency for:
Hill, AV
Wellcome Trust More from this funder
Gates Malaria Partnership, London School of Hygiene and Tropical Medicine More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
2
Issue:
8
Pages:
Article: e707
Publication date:
2007
DOI:
EISSN:
1932-6203
ISSN:
1555-5887
URN:
uuid:8e4c6b26-675b-4970-9983-7afa99a335ee
Source identifiers:
40644
Local pid:
pubs:40644

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