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Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.

Abstract:

Hepatitis C virus (HCV) infections are a major public-health concern. New antiviral drugs are needed urgently to complement and improve the efficacy of current chemotherapies. The morphogenesis of HCV represents an interesting, and still unexploited, novel molecular target. alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/vir.0.81503-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Publisher:
Microbiology Society Publisher's website
Journal:
Journal of general virology Journal website
Volume:
87
Issue:
Pt 4
Pages:
861-871
Publication date:
2006-04-01
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Source identifiers:
99867
Language:
English
Keywords:
Pubs id:
pubs:99867
UUID:
uuid:8e47963b-28b4-4712-8d4a-4607d03d258d
Local pid:
pubs:99867
Deposit date:
2012-12-19

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