Journal article icon

Journal article

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.

Abstract:

Hepatitis C virus (HCV) infections are a major public-health concern. New antiviral drugs are needed urgently to complement and improve the efficacy of current chemotherapies. The morphogenesis of HCV represents an interesting, and still unexploited, novel molecular target. alpha-Glucosidase inhibitors derived from the glucose analogue deoxynojirimycin (DNJ) inhibit viral morphogenesis in cellulo via perturbation of the N-glycosylation pathway and hence the misfolding of viral glycoproteins t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1099/vir.0.81503-0

Authors


Roingeard, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Dubuisson, J More by this author
Expand authors...
Publisher:
Microbiology Society Publisher's website
Journal:
The Journal of general virology Journal website
Volume:
87
Issue:
Pt 4
Pages:
861-871
Publication date:
2006-04-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:8e47963b-28b4-4712-8d4a-4607d03d258d
Source identifiers:
99867
Local pid:
pubs:99867

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP