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Journal article

Expression of alternatively spliced forms of the CD44 extracellular-matrix receptor on human lung carcinomas.

Abstract:

Expression of isoforms of the CD44 hyaluronan receptor/lymph-node endothelial receptor by human tumour cells is thought to play a role in tumour growth and metastasis. These isoforms which vary in the length of the extracellular domain are generated by differential RNA splicing that involves the 10 alternative exons (v1 to v10) encoding the membrane proximal region of the molecule. Several tumours have been shown to over-express CD44 containing the v6 exon, and this, together with other evide...

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Publication status:
Published

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Journal:
International journal of cancer. Supplement = Journal international du cancer. Supplement
Volume:
8
Pages:
110-115
Publication date:
1994-01-01
ISSN:
0898-6924
Source identifiers:
102477

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