Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

Journal article

Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up information on carriers is limited and genetic heterogeneity makes counselling and management in PJS difficult. Here we report the analysis of the LKB1/STK11 locus in a series of 33 PJS families, and e...

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Authors: Lim, W; Hearle, N; Shah, B; Murday, V; Hodgson, S

• Publication status: Published
• Journal: British journal of cancer
• Volume: 89
• Issue: 2
• Pages: 308-313
• Publication date: 2003-07-01
• DOI: 10.1038/sj.bjc.6601030
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Risk Factors; Peutz-Jeghers Syndrome; Follow-Up Studies; Female; Adult; Middle Aged; Genotype; Germ-Line Mutation; Male; Gastrointestinal Neoplasms; Phenotype; Aged; Protein-Serine-Threonine Kinases; Genetic Predisposition to Disease; Breast Neoplasms; Humans