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Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.

Abstract:

Induction of mild states of hyperketonemia may improve physical and cognitive performance. In this study, we determined the kinetic parameters, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, a ketone monoester administered in the form of a meal replacement drink to healthy human volunteers. Plasma levels of β-hydroxybutyrate and acetoacetate were elevated following administration of a single dose of the ketone monoester, whether at 140, 357, or 714 mg/kg body weight, whi...

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Publication status:
Published

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Publisher copy:
10.1016/j.yrtph.2012.04.008

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Tchabanenko, K More by this author
Pawlosky, R More by this author
Todd King, M More by this author
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Journal:
Regulatory toxicology and pharmacology : RTP
Volume:
63
Issue:
3
Pages:
401-408
Publication date:
2012-08-05
DOI:
EISSN:
1096-0295
ISSN:
0273-2300
URN:
uuid:8e3b5c91-12e6-453a-ac7f-a266e19e4926
Source identifiers:
329036
Local pid:
pubs:329036

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