Chemoreceptor drives and short sleep-wake cycles during hypoxia: a simulation study.

Journal article

We used a Grodins-type mathematical model of the cardio-pulmonary system to investigate the cycling behaviour of the respiratory system during hypoxia in response to changes of state between waking and sleeping, namely a diminution of respiratory chemosensitivity during sleep. Shifts between waking and sleeping were triggered by various combinations of threshold values for PAO2. Mild or moderate hypoxia was simulated by values of inspired O2 concentration between 13% and 16% (normal 21%). In ...

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Authors: Saunders, K; Stradling, J

• Publication status: Published
• Journal: Annals of biomedical engineering
• Volume: 21
• Issue: 5
• Pages: 465-474
• Publication date: 1993-01-01
• DOI: 10.1007/bf02584329
• EISSN: 1573-9686
• ISSN: 0090-6964
• Language: English
• Keywords: Models, Biological; Humans; Chemoreceptor Cells; Periodicity; Anoxia; Oxygen; Respiration; Sleep Stages