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Chemoreceptor drives and short sleep-wake cycles during hypoxia: a simulation study.

Abstract:

We used a Grodins-type mathematical model of the cardio-pulmonary system to investigate the cycling behaviour of the respiratory system during hypoxia in response to changes of state between waking and sleeping, namely a diminution of respiratory chemosensitivity during sleep. Shifts between waking and sleeping were triggered by various combinations of threshold values for PAO2. Mild or moderate hypoxia was simulated by values of inspired O2 concentration between 13% and 16% (normal 21%). In ...

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Publication status:
Published

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Publisher copy:
10.1007/bf02584329

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Annals of biomedical engineering More from this journal
Volume:
21
Issue:
5
Pages:
465-474
Publication date:
1993-01-01
DOI:
EISSN:
1573-9686
ISSN:
0090-6964
Language:
English
Keywords:
Pubs id:
pubs:35816
UUID:
uuid:8e386a87-1399-48e1-8785-03c43fa9c05f
Local pid:
pubs:35816
Source identifiers:
35816
Deposit date:
2012-12-19

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