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Cyclic AMP promotes the survival of dopaminergic neurons in vitro and protects them from the toxic effects of MPP+.

Abstract:

We have studied how stimulation of protein kinase C and cAMP-dependent protein kinases affect the development of mesencephalic dopaminergic neurons in vitro. IGF-I and bFGF did not activate either second messenger system nor affect the survival of dopaminergic neurons but stimulated dopamine uptake per neuron. Phorbol esters, which stimulate protein kinase C, had no effect on dopamine uptake. Dibutyryl-cAMP caused an increase in dopamine uptake, which was blocked with (Rp)-cAMPS, a specific i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of neural transmission. Supplementum
Volume:
46
Issue:
46
Pages:
217-228
Publication date:
1995-01-05
ISSN:
0303-6995
URN:
uuid:8e379f5f-d9b7-47ca-97e8-6ae9bfec53f3
Source identifiers:
107542
Local pid:
pubs:107542

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