Journal article icon

Journal article

In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Abstract:

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with variations of the copy number of pfmdr1. The median drug concentrations that inhibit 50% of parasite growth (IC(50)s) were 41 nM (interquartile range [IQR], 18 to 73 nM), 50 nM (IQR, 29 to 96 nM), 32 nM (IQR, 17 to 46 nM), and 2 nM (IQR, 1 to 3 n...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/aac.00638-09

Authors


Abdirahman, A More by this author
Rippert, A More by this author
Expand authors...
Journal:
Antimicrobial agents and chemotherapy
Volume:
53
Issue:
12
Pages:
5069-5073
Publication date:
2009-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:8e31e48e-50e6-4a24-8911-79adbbf8111a
Source identifiers:
41437
Local pid:
pubs:41437

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP