Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus.

Journal article

Mechanisms that control neuronal gain allow for adaptive rescaling to synaptic inputs of varying strengths or frequencies. Here, we show that unitary IPSPs (uIPSPs) modulate gain and unitary EPSP (uEPSP)-action potential coupling in mossy cells (MCs) from rat hippocampal slices. Mossy fibre-evoked uEPSCs were large, facilitated and were suppressed by the group II metabotropic glutamate agonist LY354740. Conversely, uIPSCs were smaller, depressed and were not affected by LY354740, but exerted ...

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Authors: Kerr, A; Capogna, M

• Publication status: Published
• Journal: Journal of physiology
• Volume: 578
• Issue: Pt 2
• Pages: 451-470
• Publication date: 2007-01-01
• DOI: 10.1113/jphysiol.2006.121608
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Hippocampus; Rats, Sprague-Dawley; Electric Impedance; Action Potentials; Rats; 2-Amino-5-phosphonovalerate; Inhibitory Postsynaptic Potentials; Sodium Channels; Animals; Excitatory Postsynaptic Potentials; Mossy Fibers, Hippocampal; Pilocarpine; Tetrodotoxin; Bicyclo Compounds; Cell Membrane; Interneurons; Neurons; Pyridazines; Synaptic Transmission; Quinoxalines; Male; Patch-Clamp Techniques; Electric Capacitance