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Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Abstract:

Human cells utilize a variety of complex DNA repair mechanisms in order to combat constant mutagenic and cytotoxic threats from both exogenous and endogenous sources. The RecQ family of DNA helicases, which includes Bloom helicase (BLM), plays an important function in DNA repair by unwinding complementary strands of duplex DNA as well as atypical DNA structures such as Holliday junctions. Mutations of the BLM gene can result in Bloom syndrome, an autosomal recessive disorder associated with c...

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Publisher copy:
10.1016/j.bmcl.2013.08.025

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Bioorganic and Medicinal Chemistry Letters More from this journal
Volume:
23
Issue:
20
Pages:
5660-5666
Publication date:
2013-10-15
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:430064
UUID:
uuid:8e1689ef-63c9-4292-b846-c7cbcfb0d932
Local pid:
pubs:430064
Source identifiers:
430064
Deposit date:
2013-11-17

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