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Journal article

Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection

Abstract:

The role of NS1-specific antibodies in the pathogenesis of dengue virus infection is poorly understood. Here we investigate the immunoglobulin responses of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF) to NS1. Antibody responses to recombinant-NS1 are assessed in serum samples obtained throughout illness of patients with acute secondary DENV1 and DENV2 infection by ELISA. NS1 antibody titres are significantly higher in patients with DHF compared to those with DF for both ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07667-z

Authors


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Centre for Dengue Research More from this funder
University of Sri Jayewardenapura More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 5242
Publication date:
2018-12-07
Acceptance date:
2018-11-13
DOI:
EISSN:
2041-1723
Pubs id:
pubs:944209
URN:
uri:8e1503f9-1d69-4fc0-afb5-50875837243f
UUID:
uuid:8e1503f9-1d69-4fc0-afb5-50875837243f
Local pid:
pubs:944209

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