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Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

Abstract:

BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway of energy metabolism that power motility, a feature that facilitates gamete encounter and fertilization, is unknown. METHODS: Plasmodium berghei microgametes were purified and analysed by whole-cell ...

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Publisher copy:
10.1186/1475-2875-13-315

Authors


Talman, AM More by this author
Prieto, JH More by this author
Marques, S More by this author
Ubaida-Mohien, C More by this author
Lawniczak, M More by this author
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Publisher:
BioMed Central Ltd.
Journal:
Malaria journal
Volume:
13
Issue:
1
Pages:
315
Publication date:
2014
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:8e1456ff-d841-4326-a4ce-4f7b8638634b
Source identifiers:
482188
Local pid:
pubs:482188

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