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The integrin receptor in biologically relevant bilayers: insights from molecular dynamics simulations

Abstract:

Integrins are heterodimeric (αβ) cell surface receptors that are potential therapeutic targets for a number of diseases. Despite the existence of structural data for all parts of integrins, the structure of the complete integrin receptor is still not available. We have used available structural data to construct a model of the complete integrin receptor in complex with talin F2-F3 domain. It has been shown that the interactions of integrins with their lipid environment are crucial for their f...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00232-016-9908-z

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Vattulainen, I More by this author
Campbell, ID More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Wellcome Trust More from this funder
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Grant:
Center of Excellence program
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Grant:
Advanced Grant project CROWDED-PRO-LIPIDS
Publisher:
Springer US Publisher's website
Journal:
Journal of Membrane Biology Journal website
Volume:
250
Issue:
4
Pages:
337–351
Publication date:
2016-07-27
DOI:
EISSN:
1432-1424
ISSN:
0022-2631
URN:
uuid:8e122851-600d-490c-8f7b-86803bed9b81
Source identifiers:
623924
Local pid:
pubs:623924

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