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Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.

Abstract:

CD1 molecules are beta(2)m-associated HLA class-I-like glycoproteins which have the unique ability to present glycolipid and phospholipid antigens to specific T lymphocytes. To study the biology of CD1 and its role in human disease we developed novel techniques for generation of recombinant CD1/lipid complexes by in vitro refolding. Fluorescent tetrameric complexes made from soluble recombinant CD1d/alpha-galactosylceramide complexes allowed highly sensitive and specific ex vivo and in vitro ...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.2003.1267

Authors


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Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
358
Issue:
1433
Pages:
875-877
Publication date:
2003-05-01
Event title:
Discussion Meeting of the Royal-Society
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
Source identifiers:
12063
Keywords:
Pubs id:
pubs:12063
UUID:
uuid:8e0d58c7-fb88-4a4b-95bf-8b38a9e14ed1
Local pid:
pubs:12063
Deposit date:
2012-12-19

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