- Abstract:
-
CD1 molecules are beta(2)m-associated HLA class-I-like glycoproteins which have the unique ability to present glycolipid and phospholipid antigens to specific T lymphocytes. To study the biology of CD1 and its role in human disease we developed novel techniques for generation of recombinant CD1/lipid complexes by in vitro refolding. Fluorescent tetrameric complexes made from soluble recombinant CD1d/alpha-galactosylceramide complexes allowed highly sensitive and specific ex vivo and in vitro ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1098/rstb.2003.1267
-
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- Volume:
- 358
- Issue:
- 1433
- Pages:
- 875-877
- Publication date:
- 2003-05-05
- DOI:
- EISSN:
-
1471-2970
- ISSN:
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0962-8436
- URN:
-
uuid:8e0d58c7-fb88-4a4b-95bf-8b38a9e14ed1
- Source identifiers:
-
12063
- Local pid:
- pubs:12063
- Copyright date:
- 2003
Conference
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.
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