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Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria.

Abstract:

The therapeutic efficacy and toxicity of a combination of low dose mefloquine (15 mg/kg) plus artesunate 10 mg/kg in one day (MA) was compared with the currently used regimen of high dose mefloquine (25 mg/kg) (MQ) in 552 patients with uncomplicated falciparum malaria in an area of multi-drug resistance on the Thai-Burmese border. MA gave faster clinical and parasitological responses and prevented early treatment failure; 15 patients in the MQ group (6%) were early failures (< 9 d) compare...

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Publication status:
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Authors


Luxemburger, C More by this author
ter Kuile, FO More by this author
Bradol, JH More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
88
Issue:
2
Pages:
213-217
Publication date:
1994
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:8e0b51c3-5353-40b2-bffc-b35917266cc5
Source identifiers:
28653
Local pid:
pubs:28653

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