Book section
Structural insights into Notch receptor-ligand interactions
- Abstract:
-
Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functional assays have enabled us to define the molecular basis of the core receptor/ligand interaction and given new insights into the architecture of the Notch complex at the cell surfa...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1007/978-3-319-89512-3_2
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Authors
Bibliographic Details
- Publisher:
- Springer, Cham Publisher's website
- Volume:
- 1066
- Pages:
- 33-46
- Series:
- Advances in Experimental Medicine and Biology
- Host title:
- Molecular Mechanisms of Notch Signaling
- Publication date:
- 2018-07-19
- DOI:
- EISSN:
-
2214-8019
- ISSN:
-
0065-2598
- Pmid:
-
30030820
- Source identifiers:
-
891435
- ISBN:
- 9783319895116
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:891435
- UUID:
-
uuid:8dfc2ab0-f0d3-4921-9868-0a70815943b6
- Local pid:
- pubs:891435
- Deposit date:
- 2018-11-07
Terms of use
- Copyright holder:
- Springer International Publishing AG, part of Springer Nature
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Springer International Publishing AG, part of Springer Nature.
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