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Structural insights into Notch receptor-ligand interactions

Abstract:

Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functional assays have enabled us to define the molecular basis of the core receptor/ligand interaction and given new insights into the architecture of the Notch complex at the cell surfa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/978-3-319-89512-3_2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Catherines College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-7297-7708
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0001-9287-8053
Publisher:
Springer, Cham Publisher's website
Volume:
1066
Pages:
33-46
Series:
Advances in Experimental Medicine and Biology
Host title:
Molecular Mechanisms of Notch Signaling
Publication date:
2018-07-19
DOI:
EISSN:
2214-8019
ISSN:
0065-2598
Pubs id:
pubs:891435
URN:
uri:8dfc2ab0-f0d3-4921-9868-0a70815943b6
UUID:
uuid:8dfc2ab0-f0d3-4921-9868-0a70815943b6
Local pid:
pubs:891435
ISBN:
978-3-319-89511-6
Language:
English
Keywords:

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