- Abstract:
-
To better understand the roles of TGF-beta in bone metabolism, we investigated osteoclast survival in response TGF-beta and found that TGF-beta inhibited apoptosis. We examined the receptors involved in promotion of osteoclast survival and found that the canonical TGF-beta receptor complex is involved in the survival response. The upstream MEK kinase TAK1 was rapidly activated following TGF-beta treatment. Since osteoclast survival involves MEK, AKT, and NFkappaB activation, we examined TGF-b...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.yexcr.2008.06.006
-
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- Journal:
- Experimental cell research
- Volume:
- 314
- Issue:
- 15
- Pages:
- 2725-2738
- Publication date:
- 2008-09-05
- DOI:
- EISSN:
-
1090-2422
- ISSN:
-
0014-4827
- URN:
-
uuid:8df9bce7-88aa-481b-8957-4f6a7a6bb040
- Source identifiers:
-
223526
- Local pid:
- pubs:223526
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.
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