Journal article icon

Journal article

TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

Abstract:

To better understand the roles of TGF-beta in bone metabolism, we investigated osteoclast survival in response TGF-beta and found that TGF-beta inhibited apoptosis. We examined the receptors involved in promotion of osteoclast survival and found that the canonical TGF-beta receptor complex is involved in the survival response. The upstream MEK kinase TAK1 was rapidly activated following TGF-beta treatment. Since osteoclast survival involves MEK, AKT, and NFkappaB activation, we examined TGF-b...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.yexcr.2008.06.006

Authors


Gingery, A More by this author
Bradley, EW More by this author
Pederson, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Expand authors...
Journal:
Experimental cell research
Volume:
314
Issue:
15
Pages:
2725-2738
Publication date:
2008-09-05
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
URN:
uuid:8df9bce7-88aa-481b-8957-4f6a7a6bb040
Source identifiers:
223526
Local pid:
pubs:223526

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP