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Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability.

Abstract:

RATIONALE: Compromised development of blood vessel walls leads to vascular instability that may predispose to aneurysm with risk of rupture and lethal hemorrhage. There is currently a lack of insight into developmental insults that may define the molecular and cellular characteristics of initiating and perpetrating factors in adult aneurismal disease. OBJECTIVE: To investigate a role for the actin-binding protein thymosin β4 (Tβ4), previously shown to be proangiogenic, in mural cell developme...

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Publication status:
Published

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Authors


Rossdeutsch, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Circulation research
Volume:
111
Issue:
4
Pages:
e89-102
Publication date:
2012-08-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:8df92014-3401-4c82-98a2-3b190d33e9e9
Source identifiers:
341185
Local pid:
pubs:341185

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