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Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury.

Abstract:

A key component in the response of the nervous system to injury is the proliferation and switch to a "proinflammatory" phenotype by microglia (microgliosis). In situations where the blood-brain barrier is intact, microglial numbers increase via the proliferation and chemotaxis of resident microglia; however, there is limited knowledge regarding the factors mediating this response. After peripheral nerve injury, a dorsal horn microgliosis develops, which directly contributes to the development...

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
30
Issue:
15
Pages:
5437-5450
Publication date:
2010-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:8df3dd61-fa6d-4556-91a9-fd71f0e0a0c1
Source identifiers:
365745
Local pid:
pubs:365745

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