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Journal article

Inherited variability of tumor necrosis factor production and susceptibility to infectious disease.

Abstract:

Tumor necrosis factor (TNF) is a critical mediator of host defense against infection but may cause severe pathology when produced in excess. Individuals vary in the amount of TNF produced when their peripheral blood mononuclear cells are stimulated in vitro, and family studies indicate that much of this variability is genetically determined. Since the TNF response to infection is partly regulated at the transcriptional level, TNF promoter polymorphisms have been the subject of intense interes...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Proceedings of the Association of American Physicians
Volume:
111
Issue:
4
Pages:
290-298
Publication date:
1999-01-01
DOI:
EISSN:
1525-1381
ISSN:
1081-650X
Source identifiers:
26004

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