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Journal article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Abstract:

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fa...

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Publication status:
Published

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Publisher copy:
10.2337/db11-0415

Authors


Strawbridge, RJ More by this author
Prokopenko, I More by this author
Ahlqvist, E More by this author
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Journal:
Diabetes
Volume:
60
Issue:
10
Pages:
2624-2634
Publication date:
2011-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:8def60af-3020-48bd-8d73-3bb696563d12
Source identifiers:
186483
Local pid:
pubs:186483

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