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Concentration-normalized electroanalytical assaying of exosomal markers.

Abstract:

Exosomes are both active in mediating intracellular communication and potentially present a potent cargo of disease biomarkers to an assay. The robust evaluation of exosomal markers could lead to a paradigm shift in clinical analysis and associated care. To date, much of this has been hindered by issues of sample preparation and assay signal-to-noise. We introduce here the use of ultrasensitive electrochemical impedance spectroscopy to quantify both external (tetraspanin) and internal (synten...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Tofaris, G
Davis, J
Grant:
EP/M006204/1
EP/M006204/1
Publisher:
American Chemical Society
Journal:
Analytical Chemistry More from this journal
Volume:
89
Issue:
5
Pages:
3184-3190
Publication date:
2017-01-01
Acceptance date:
2017-01-27
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Language:
English
Pubs id:
pubs:680815
UUID:
uuid:8de336d6-db46-4f2e-9ddd-16144c3d6b00
Local pid:
pubs:680815
Source identifiers:
680815
Deposit date:
2017-06-07

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