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Meta-analysis of small randomized controlled trials in surgery may be unreliable.

Abstract:

BACKGROUND: Meta-analysis of randomized controlled trials (RCTs) should provide reliable evidence about the effects of interventions. This may be less reliable when only small trials are available. METHODS: The sample size was determined for all surgical RCTs included in Cochrane Collaboration systematic reviews. The difficulty in interpreting meta-analysis of small trials is illustrated using two specific reviews. RESULTS: The typical sample size for surgical RCTs was small with a median of...

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Publication status:
Published

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Publisher copy:
10.1002/bjs.6988

Authors


Rerkasem, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Journal:
The British journal of surgery
Volume:
97
Issue:
4
Pages:
466-469
Publication date:
2010-04-05
DOI:
EISSN:
1365-2168
ISSN:
0007-1323
URN:
uuid:8ddb1373-d812-4bdb-a4ff-e07fc8a4daeb
Source identifiers:
119975
Local pid:
pubs:119975

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