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Journal article

Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4.

Abstract:

Non-obese diabetic (NOD) mice were injected with a rat monoclonal antibody to CD4 from birth every two weeks through 6 months of age. These animals gained weight normally but < 11% of their spleen T cells were CD4+, compared with 28% of CD4+ in controls injected with polyclonal rat IgG. The reduction in CD4 cell percentage was associated with a reduction in the number of cells in the thymus and spleen following the injection. CD4+ cells which survived the injections were nevertheless able ...

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Publication status:
Published

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Publisher copy:
10.1006/jaut.1993.1026

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of autoimmunity More from this journal
Volume:
6
Issue:
3
Pages:
301-310
Publication date:
1993-06-01
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Language:
English
Keywords:
Pubs id:
pubs:471
UUID:
uuid:8ddadad6-f88b-43b3-bae6-ad913343af1e
Local pid:
pubs:471
Source identifiers:
471
Deposit date:
2012-12-19

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