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Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.

Abstract:

Nitric oxide (NO) generated from neuronal nitric oxide synthase (NOS-1) in intrinsic cardiac ganglia has been implicated in parasympathetic-induced bradycardia. We provide direct evidence that NOS-1 acts in a site-specific manner to promote cardiac vagal neurotransmission and bradycardia. NOS-1 gene transfer to the guinea pig right atrium increased protein expression and NOS-1 immunolocalization in cholinergic ganglia. It also increased the release of acetylcholine and enhanced the heart rate...

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Publication status:
Published

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Journal:
Circulation research More from this journal
Volume:
91
Issue:
12
Pages:
1089-1091
Publication date:
2002-12-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:105010
UUID:
uuid:8dd94244-1c5f-4e97-b645-0b63648971c8
Local pid:
pubs:105010
Source identifiers:
105010
Deposit date:
2012-12-19

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