Journal article
The cardiomyocyte RNA-binding proteome: links to intermediary metabolism and heart disease
- Abstract:
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RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA interactome capture and RBDmap. Together, these yielded 1,148 RBPs, 391 of which are shared with all other available mammalian RBP repertoires, while 393 are thus far unique to cardiomyocytes. RBDmap further identified 568 regions of RNA contact within 368 ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 13.4MB)
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- Publisher copy:
- 10.1016/j.celrep.2016.06.084
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Authors
Funding
+ Medical Research Council
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Funding agency for:
Castello, A
Grant:
Career Development Award (#MR/L019434/1
National Health and Medical Research Council of Australia
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Gretel and Gordon Bootes Foundation
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 16
- Issue:
- 5
- Pages:
- 1456–1469
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-06-07
- DOI:
- EISSN:
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2211-1247
- ISSN:
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2211-1247
- Source identifiers:
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635396
Item Description
- Keywords:
- Pubs id:
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pubs:635396
- UUID:
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uuid:8dcddb05-fc25-4b96-97d9-4ab76eee03ef
- Local pid:
- pubs:635396
- Deposit date:
- 2016-07-26
Terms of use
- Copyright holder:
- Liao et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). Open Access funded by the European Research Council. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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