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The cardiomyocyte RNA-binding proteome: links to intermediary metabolism and heart disease

Abstract:

RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA interactome capture and RBDmap. Together, these yielded 1,148 RBPs, 391 of which are shared with all other available mammalian RBP repertoires, while 393 are thus far unique to cardiomyocytes. RBDmap further identified 568 regions of RNA contact within 368 ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.06.084

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Castello, A
Gretel and Gordon Bootes Foundation More from this funder
National Health and Medical Research Council of Australia More from this funder
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Grant:
Advanced Grant ERC-2011-ADG_20110310
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
16
Issue:
5
Pages:
1456–1469
Publication date:
2016-07-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:8dcddb05-fc25-4b96-97d9-4ab76eee03ef
Source identifiers:
635396
Local pid:
pubs:635396
Paper number:
5

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