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A retrospective cohort study identifying the principal pathological features useful in the diagnosis of inclusion body myositis

Abstract:

OBJECTIVE: The current pathological diagnostic criteria for sporadic inclusion body myositis (IBM) lack sensitivity. Using immunohistochemical techniques abnormal protein aggregates have been identified in IBM, including some associated with neurodegenerative disorders. Our objective was to investigate the diagnostic utility of a number of markers of protein aggregates together with mitochondrial and inflammatory changes in IBM. DESIGN: Retrospective cohort study. The sensitivity of pathologi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2013-004552

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Publication date:
2014-04-28
Acceptance date:
2014-03-18
DOI:
EISSN:
2044-6055
Source identifiers:
463345
Language:
English
Keywords:
UUID:
uuid:8dc3ca5b-9a40-4963-b225-df4003dd48f2
Local pid:
pubs:463345
Deposit date:
2014-06-16

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