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Activation of the Ca2+ "receptor" on the osteoclast by Ni2+ elicits cytosolic Ca2+ signals: evidence for receptor activation and inactivation, intracellular Ca2+ redistribution, and divalent cation modulation.

Abstract:

Earlier studies have demonstrated that a high (mM) extracellular Ca2+ concentration triggers intracellular [Ca2+] signals with a consequent inhibition of bone resorptive activity. We now report that micromolar concentrations of the divalent cation, Ni2+, elicited rapid and concentration-dependent elevations of cytosolic [Ca2+]. The peak change in cytosolic [Ca2+] increased monotonically with the application of [Ni2+] in the 50-5,000 microM range in solutions containing 1.25 mM-[Ca2+] and 0.8 ...

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Publisher copy:
10.1002/jcp.1041550116

Authors


Shankar, VS More by this author
Moonga, BS More by this author
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Journal:
Journal of cellular physiology
Volume:
155
Issue:
1
Pages:
120-129
Publication date:
1993-04-05
DOI:
EISSN:
1097-4652
ISSN:
0021-9541
URN:
uuid:8dc2d9ff-13e6-4127-b8c9-d512c4e4af97
Source identifiers:
475703
Local pid:
pubs:475703

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