- Abstract:
-
Earlier studies have demonstrated that a high (mM) extracellular Ca2+ concentration triggers intracellular [Ca2+] signals with a consequent inhibition of bone resorptive activity. We now report that micromolar concentrations of the divalent cation, Ni2+, elicited rapid and concentration-dependent elevations of cytosolic [Ca2+]. The peak change in cytosolic [Ca2+] increased monotonically with the application of [Ni2+] in the 50-5,000 microM range in solutions containing 1.25 mM-[Ca2+] and 0.8 ...
Expand abstract - Publisher copy:
- 10.1002/jcp.1041550116
-
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- Journal:
- Journal of cellular physiology
- Volume:
- 155
- Issue:
- 1
- Pages:
- 120-129
- Publication date:
- 1993-04-05
- DOI:
- EISSN:
-
1097-4652
- ISSN:
-
0021-9541
- URN:
-
uuid:8dc2d9ff-13e6-4127-b8c9-d512c4e4af97
- Source identifiers:
-
475703
- Local pid:
- pubs:475703
- Copyright date:
- 1993
Journal article
Activation of the Ca2+ "receptor" on the osteoclast by Ni2+ elicits cytosolic Ca2+ signals: evidence for receptor activation and inactivation, intracellular Ca2+ redistribution, and divalent cation modulation.
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