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Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression.

Abstract:

Annexin 1 (ANX-A1) exerts antimigratory actions in several models of acute and chronic inflammation. This is related to its ability to mimic the effect of endogenous ANX-A1 that is externalized on neutrophil adhesion to the postcapillary endothelium. In the present study we monitored ANX-A1 expression and localization in intravascular and emigrated neutrophils, using a classical model of rat peritonitis. For this purpose, a pair of antibodies raised against the ANX-A1 N-terminus (ie, able to ...

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Publication status:
Published

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Authors


Oliani, SM More by this author
Paul-Clark, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Flower, RJ More by this author
Perretti, M More by this author
Journal:
The American journal of pathology
Volume:
158
Issue:
2
Pages:
603-615
Publication date:
2001-02-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:8db37ec5-4fd6-4819-8bd5-d6cc4b201144
Source identifiers:
114502
Local pid:
pubs:114502

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