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Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.

Abstract:

The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RN...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of virology
Volume:
78
Issue:
17
Pages:
9568-9572
Publication date:
2004-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:8da739be-e855-4084-ab42-c1a02ff467fb
Source identifiers:
20885
Local pid:
pubs:20885

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