- Abstract:
-
The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RN...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.78.17.9568-9572.2004
-
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- Journal:
- Journal of virology
- Volume:
- 78
- Issue:
- 17
- Pages:
- 9568-9572
- Publication date:
- 2004-09-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:8da739be-e855-4084-ab42-c1a02ff467fb
- Source identifiers:
-
20885
- Local pid:
- pubs:20885
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.
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