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Journal article

Generation of large insert yeast artificial chromosome libraries.

Abstract:
The development of YAC cloning technology has directly enhanced the relationship among genetic, physical, and functional mapping of genomes. Because of their large size, YACs have enabled the rapid construction of physical maps by ordered clone mapping and contig building, and they complement other molecular approaches for mapping complex genomes. Large insert libraries are constructed by size fractionating large DNA embedded in agarose and protecting DNA from degradation with polyamines.
Publication status:
Published

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Publisher copy:
10.1007/bf02752259

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Molecular biotechnology
Volume:
8
Issue:
2
Pages:
147-153
Publication date:
1997-10-05
DOI:
EISSN:
1559-0305
ISSN:
1073-6085
URN:
uuid:8da352de-41ca-4ea7-839c-409c5b1c7209
Source identifiers:
36130
Local pid:
pubs:36130

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