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High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

Abstract:

The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More from this funder
Name:
Bloodwise
Funding agency for:
Roy, A
Grant:
Translational Research Training in Hematology Fellowship
More from this funder
Name:
European Hematology Association/American Society of Hematology
Funding agency for:
Roy, A
Grant:
Translational Research Training in Hematology Fellowship
More from this funder
Name:
National Institute for Health Research
Grant:
OxfordNIHRBiomedicalCentrebasedatOxfordUniversityHospitalsNHSTrust
NIHRBiomedicalCentrebasedatImperialCollegeLondon
UniversityofOxford
Publisher:
Elsevier
Journal:
Clinical Immunology More from this journal
Volume:
183
Pages:
8-16
Publication date:
2017-06-20
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
Language:
English
Keywords:
Pubs id:
pubs:702382
UUID:
uuid:8da2807c-db03-4b2c-a7e7-1c4c6d177745
Local pid:
pubs:702382
Deposit date:
2017-07-10

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