Journal article
High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans
- Abstract:
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The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consis...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(pdf, 1.5MB)
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- Publisher copy:
- 10.1016/j.clim.2017.06.005
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Authors
Funding
+ European Hematology Association/American Society of Hematology
More from this funder
Funding agency for:
Roy, A
Grant:
Translational Research Training in Hematology Fellowship
+ National Institute for Health Research
More from this funder
Grant:
OxfordNIHRBiomedicalCentrebasedatOxfordUniversityHospitalsNHSTrust
NIHRBiomedicalCentrebasedatImperialCollegeLondon
UniversityofOxford
+ Bloodwise
More from this funder
Funding agency for:
Roy, A
Grant:
Translational Research Training in Hematology Fellowship
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Clinical Immunology Journal website
- Volume:
- 183
- Pages:
- 8-16
- Publication date:
- 2017-06-20
- DOI:
- EISSN:
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1521-7035
- ISSN:
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1521-6616
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:702382
- UUID:
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uuid:8da2807c-db03-4b2c-a7e7-1c4c6d177745
- Local pid:
- pubs:702382
- Deposit date:
- 2017-07-10
Terms of use
- Copyright holder:
- Roy et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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