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A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Abstract:

Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and ben...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.03.070

Authors


Frayling, TM More by this author
Beaumont, RN More by this author
Yaghootkar, H More by this author
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More from this funder
Grant:
104150/Z/14/Z
WT097835MF
Diabetes UK More from this funder
European Regional Development Fund More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
2
Pages:
327-336
Publication date:
2018-04-10
Acceptance date:
2018-03-15
DOI:
EISSN:
2211-1247
Pubs id:
pubs:835582
URN:
uri:8d991280-d8c6-400e-92ee-480a6867668b
UUID:
uuid:8d991280-d8c6-400e-92ee-480a6867668b
Local pid:
pubs:835582

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