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Thesis

Functional dyes as tools for neurophysiology

Abstract:

The aim of the project described in this thesis is to synthesise new functional molecules which interact with light for neurophysiological applications. In particular, I describe a family of amphiphilic porphyrins with large first hyperpolarisabilities which are used as SHG contrast agents and voltage-sensitive probes. In addition I detail a methodological microscopy tool and a novel caged form of a neuronal ion-channel antagonist.

Chapter 1 introduces the key concepts underlying th...

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Institution:
University of Oxford
Research group:
Harry Anderson - Molecular Engineering
Oxford college:
Lady Margaret Hall
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:8d8e7fa1-0f1d-4ff5-9f90-6915b15c1ad4
Local pid:
ora:8688

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