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Thesis

Targeting interstrand crosslink repair to improve chemotherapeutic strategies

Abstract:

Many clinically effective chemotherapeutic agents exert their toxicity through formation of DNA interstrand cross-links (ICL). These prevent the replication and transcription of DNA and if unrepaired lead to cell death.

Despite the success of ICL inducing agents in treating cancers, issues remain with a lack of sensitivity in some tumours, therapy-limiting toxicity and acquired resistance and tumour recurrence. The modulation of ICL repair could improve chemotherapy outcomes and th...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8d8c763a-195e-4e1c-b1b4-12a7bc67a2c8
Deposit date:
2018-07-04

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