MHC class I-independent recognition of NK-activating receptor KIR2DS4.

Journal article

Natural killer cells are capable of killing tumor and virus-infected cells. This killing is mediated primarily via the natural cytotoxicity receptors, including NKp46, NKp44, NKp30, and by the NKG2D receptor. Killer cell Ig-like receptors (KIRs) are mainly involved in inhibiting NK killing (inhibitory KIRs) via interaction with MHC class I molecules. Some KIRs, however, have been found to enhance NK killing when interacting with MHC class I molecules (activating KIRs). We have previously demo...

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Authors: Katz, G; Gazit, R; Arnon, T; Gonen-Gross, T; Tarcic, G

• Journal: Journal of Immunology
• Volume: 173
• Issue: 3
• Pages: 1819-1825
• Publication date: 2004-08-01
• DOI: 10.4049/jimmunol.173.3.1819
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Binding Sites; Humans; Receptors, KIR; Models, Molecular; Animals; Mutagenesis, Site-Directed; Protein Conformation; Protein Binding; Histocompatibility Antigens Class I; Transfection; Receptors, Immunologic; Cell Line, Tumor; Amino Acid Sequence; Cercopithecus aethiops; Killer Cells, Natural; Immunoglobulin G; Neoplasm Proteins; Recombinant Fusion Proteins; Immunoglobulin Fc Fragments; Sequence Alignment; COS Cells; Melanoma; Molecular Sequence Data; Sequence Homology, Amino Acid; Cytotoxicity, Immunologic; Ligands; HLA-C Antigens