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MHC class I-independent recognition of NK-activating receptor KIR2DS4.

Abstract:

Natural killer cells are capable of killing tumor and virus-infected cells. This killing is mediated primarily via the natural cytotoxicity receptors, including NKp46, NKp44, NKp30, and by the NKG2D receptor. Killer cell Ig-like receptors (KIRs) are mainly involved in inhibiting NK killing (inhibitory KIRs) via interaction with MHC class I molecules. Some KIRs, however, have been found to enhance NK killing when interacting with MHC class I molecules (activating KIRs). We have previously demo...

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Publisher copy:
10.4049/jimmunol.173.3.1819

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
173
Issue:
3
Pages:
1819-1825
Publication date:
2004-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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