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Journal article

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology.

Abstract:

Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form yet transition through life cycle stages, each having a distinct morphology. In questioning the structural processes involved in these transitions, we have identified a large calpain-like protein that contains numerous GM6 repeats (ClpGM6) involved in determining T. brucei cell shape, size, and form. ClpGM6 is a cytoskeletal protein located within the flagellum along the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201312067

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Wellcome Trust More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
206
Issue:
3
Pages:
377-384
Publication date:
2014-08-01
Acceptance date:
2014-06-24
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Source identifiers:
479285
Language:
English
Keywords:
Pubs id:
pubs:479285
UUID:
uuid:8d819346-024d-43bd-9700-1d0dc945f598
Local pid:
pubs:479285
Deposit date:
2014-08-17

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