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Osmolarity effects on bovine articular chondrocytes during three-dimensional culture in alginate beads.

Abstract:

OBJECTIVE: With the development of engineered cartilage, the determination of the appropriate culture conditions is vital in order to maximize extracellular matrix synthesis. As osmolarity could affect the fate of chondrocytes, the purpose of this study was to determine the effects of osmolarity on chondrocytes during relatively long-term culture. DESIGN: Bovine articular chondrocytes were cultured in alginate beads in a biocarbonate free system at 280, 380 and 550 mOsm at pH 7.4 for up to 1...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2009.10.003

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
18
Issue:
3
Pages:
433-439
Publication date:
2010-03-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:8d749e5f-cf31-4c7c-b461-87f00a1951ba
Source identifiers:
108491
Local pid:
pubs:108491

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