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The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes

Abstract:

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause severe malaria appear to increase expression of a restricted but poorly defined subset of the PfEMP1 variant, surface antigens. PfEMP1s are major targets of protective immunity....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pbio.2004328

Authors


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National Health and Medical Research Council More from this funder
Australian Department of Foreign Affairs and Trade More from this funder
Victorian State Government More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
16
Issue:
3
Pages:
e2004328
Publication date:
2018-03-12
Acceptance date:
2018-02-16
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Pubs id:
pubs:831392
URN:
uri:8d745382-1045-4b5a-ad45-faffcfc38c10
UUID:
uuid:8d745382-1045-4b5a-ad45-faffcfc38c10
Local pid:
pubs:831392
Language:
English
Keywords:

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