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Isolation of CA dinucleotide repeats close to D6S105; linkage disequilibrium with haemochromatosis.

Abstract:

The gene for hereditary haemochromatosis (HC) is linked to HLA-A and D6S105 on chromosome 6p. Both markers have also been reported to display linkage disequilibrium with the disease. However, their physical localization relative to one another has not been established. We demonstrate by fluorescent in situ hybridisation that D6S105 lies at least 1-2 Mb telomeric of HLA-A. The haemochromatosis critical region extending from proximal of HLA-A to distal of D6S105 is therefore large. To improve t...

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Publication status:
Published

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Journal:
Human molecular genetics More from this journal
Volume:
3
Issue:
11
Pages:
2043-2046
Publication date:
1994-11-01
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
Pubs id:
pubs:35722
UUID:
uuid:8d71294d-3740-4a0f-a59f-a20b01ad8d30
Local pid:
pubs:35722
Source identifiers:
35722
Deposit date:
2012-12-19

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