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How Forster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology.

Abstract:

Herein we discuss how FRET imaging can contribute at various stages to delineate the function of the proteome. Therefore, we briefly describe FRET imaging techniques, the selection of suitable FRET pairs and potential caveats. Furthermore, we discuss state-of-the-art FRET-based screening approaches (underpinned by protein interaction network analysis using computational biology) and preclinical intravital FRET-imaging techniques that can be used for functional validation of candidate hits (no...

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Publication status:
Published

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Publisher copy:
10.1002/cphc.201000866

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Journal:
Chemphyschem : a European journal of chemical physics and physical chemistry More from this journal
Volume:
12
Issue:
3
Pages:
442-461
Publication date:
2011-02-01
DOI:
EISSN:
1439-7641
ISSN:
1439-4235
Language:
English
Keywords:
Pubs id:
pubs:124628
UUID:
uuid:8d6b6449-d4de-46ac-9923-87c9618d133e
Local pid:
pubs:124628
Source identifiers:
124628
Deposit date:
2012-12-19

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