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Single-molecule analysis of G protein-coupled receptor stoichiometry: Approaches and limitations

Abstract:

How G protein-coupled receptors (GPCRs) are organized at the cell surface remains highly contentious. Single-molecule (SM) imaging is starting to inform this debate as receptor behavior can now be visualized directly, without the need for interpreting ensemble data. The limited number of SM studies of GPCRs undertaken to date have strongly suggested that dimerization is at most transient, and that most receptors are monomeric at any given time. However, even SM data has its caveats and needs ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.tips.2017.10.005

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
ORCID:
0000-0001-5531-9244
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Klenerman, D More by this author
Publisher:
Elsevier Publisher's website
Journal:
Trends in Pharmacological Sciences Journal website
Volume:
39
Issue:
2
Pages:
96-108
Publication date:
2017-11-06
Acceptance date:
2017-10-10
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
Pubs id:
pubs:746060
URN:
uri:8d689fa4-c62e-450c-a310-213d0c96c8af
UUID:
uuid:8d689fa4-c62e-450c-a310-213d0c96c8af
Local pid:
pubs:746060

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