Journal article
Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum
- Abstract:
-
The var gene family of Plasmodium falciparum encodes the immunodominant variant surface antigens PfEMP1. These highly polymorphic proteins are important virulence factors that mediate cytoadhesion to a variety of host tissues, causing sequestration of parasitized red blood cells in vital organs, including the brain or placenta. Acquisition of variant-specific antibodies correlates with protection against severe malarial infections; however, understanding the relationship between gene expressi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 8
- Issue:
- 4
- Pages:
- e1002451
- Publication date:
- 2012-04-12
- Acceptance date:
- 2012-02-10
- DOI:
- EISSN:
-
1553-7358
- ISSN:
-
1553-734X
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8d621cdf-ee20-4c06-a098-d1fa45f9da0e
- Local pid:
- pubs:333778
- Source identifiers:
-
333778
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Buckee and Recker
- Copyright date:
- 2012
- Notes:
- © 2012 Buckee, Recker. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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