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Meningococcal B vaccine immunogenicity in children with defects in complement and splenic function

Abstract:
Background The capsular group B meningococcal vaccine (4CMenB) is recommended for children with complement deficiencies, asplenia and splenic dysfunction, however, data on the immunogenicity of 4CMenB in these ‘at-risk’ children are missing. Methods Participants aged 2-17 years in Italy, Spain, Poland, UK and Russia with complement deficiencies, asplenia or splenic dysfunction received two doses of 4CMenB two months apart, as did healthy controls. Exogenous ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1542/peds.2017-4250

Authors


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Name:
Novartis Vaccines and Diagnostics
Publisher:
American Academy of Pediatrics
Journal:
Pediatrics More from this journal
Volume:
142
Issue:
3
Article number:
e20174250
Publication date:
2018-08-31
Acceptance date:
2018-01-29
DOI:
ISSN:
1098-4275
Pubs id:
pubs:825619
UUID:
uuid:8d5ee6e1-bb27-497d-9939-253c3f5846ad
Local pid:
pubs:825619
Source identifiers:
825619
Deposit date:
2018-02-21

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