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Thesis

Early molecular and behavioural changes associated with BDNF-TrkB signalling: insights into Huntington's disease

Abstract:

Studying the precise role of brain-derived neurotrophic factor (BDNF)-TrkB signalling in Huntington’s disease (HD) pathogenesis is challenging due to the complex interactions among diverse pathways the disease affects. By depletion of TrkB signalling, specifically from the enkephalinergic striatopallidal neurons (iSPNs), our laboratory has generated a novel mouse model (TrkbPenk-KO) which leads to an age-dependent HD-like motor dysfunction phenotype. The transcriptomic ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Minichiello Group
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-5514-0364

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Minichiello Group
Oxford college:
Keble College
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
ORCID:
0000-0002-1192-3834
More from this funder
Funder identifier:
https://ror.org/051x4wh35
Funding agency for:
Malik, MY
Grant:
INCS-2019-225
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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