Inertial cavitation at the nanoscale.
Our group has recently developed novel nano-sized drug carriers that spatially target a tumor and release their payload in the presence of ultrasound-induced inertial cavitation. To maximize drug release and distribution within the tumor, co-localization of the drug carrier and cavitation nuclei is necessary. We have recently demonstrated that rough-patterned silica nanoparticles can reduce inertial cavitation thresholds to clinically relevant levels, and will extravasate in tumors alongside ...Expand abstract
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