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Journal article

Advancing the management and control of typhoid fever: A review of the historical role of human challenge studies

Abstract:

Typhoid infection causes considerable morbidity and mortality worldwide, particularly in settings where lack of clean water and inadequate sanitation facilitate disease spread through faecal-oral transmission. Improved understanding of the pathogenesis, immune control and microbiology of Salmonella Typhi infection can help accelerate the development of improved vaccines and diagnostic tests necessary for disease control. S. Typhi is a human-restricted pathogen; therefore animal models are lim...

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Publisher copy:
10.1016/j.jinf.2014.01.006

Authors


Journal:
Journal of Infection
Volume:
68
Issue:
5
Pages:
405-418
Publication date:
2014-01-01
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
Pubs id:
pubs:463516
UUID:
uuid:8d501bbc-ff68-4c98-a034-2428f259103b
Local pid:
pubs:463516
Source identifiers:
463516
Deposit date:
2014-05-18

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