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Iminosugars as dengue virus therapeutics: Molecular mechanisms of action of a drug entering clinical trials

Abstract:

Iminosugars are a class of small molecules defined by substitution of a sugar’s ring oxygen with nitrogen. Various chemical modifications of these basic structures (e.g. alkyl chain addition off of the ring nitrogen) have been developed during the last several decades. These molecules have been considered as therapeutics for a number of pathologies including viral infection, congenital disorders of glycosylation (of both glycoproteins and glycolipids), and diabetes. This thesis fo...

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Institution:
University of Oxford
Oxford college:
Pembroke College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
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Funding agency for:
Andrew C. Sayce
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:8d4da0ce-bfa6-447d-a280-630479f898af
Local pid:
ora:11378

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